Exportar este item: EndNote BibTex

Use este identificador para citar ou linkar para este item: https://bdtd.unifal-mg.edu.br:8443/handle/tede/179
Registro completo de metadados
Campo DCValorIdioma
dc.creatorVELOSO, Clarice de Carvalho-
dc.creator.Latteshttp://lattes.cnpq.br/4513122857183761por
dc.contributor.advisor1PAIVA, Alexandre Giusti-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7032806488934374por
dc.contributor.referee1PEREZ, Andrea de Castro-
dc.contributor.referee2NASCIMENTO, Carlos Giovani de Oliveira-
dc.date.accessioned2015-05-07T23:50:00Z-
dc.date.issued2010-12-16-
dc.identifier.citationVELOSO, Clarice de Carvalho. Avaliação farmacológica do extrato hidroalcoólico das Flores de Pyrostegia venusta (Ker.) Miers. 2010. 63 f. Dissertação( Programa de Pós-Graduação em Ciências Farmacêuticas) - Universidade Federal de Alfenas, Alfenas, MG, 2010 .por
dc.identifier.urihttp://bdtd.unifal-mg.edu.br:8080/handle/tede/179-
dc.description.resumoPyrostegia venusta (Ker.) Miers (Bignoniaceae) é nativa do Cerrado Brasileiro e popularmente conhecida como “cipó-de-são-joão.” Na medicina tradicional brasileira, a Pyrostegia venusta é usada como tônico geral, bem como para o tratamento de diarréia, vitiligo, tosse e doenças comuns do sistema respiratório relacionadas à infecções, tais como bronquite, gripe e resfriado. Este estudo foi conduzido para avaliar os efeitos do extrato hidroetanólico das flores de Pyrostegia venusta (EHPv) no comportamento doentio induzido por lipopolissacarídeo em camundongos, avaliar as propriedades anti-inflamatórias e analgésicas do EHPv e o seu perfil fitoquímico. Para avaliar os efeitos do extrato hidroetanólico de Pyrostegia veusta administrado oralmente no comportamento doentio induzido por lipopolissacarídeo, os camundongos foram submetidos aos testes de nado forçado e campo aberto. O EHPv foi usado para avaliar os efeitos anti-inflamatórios e analgésicos usando os testes de edema de pata induzido por carragenina e peritonite; os testes de lambida de pata induzida por formalina e contorções abdominais induzidas por ácido acético em camundongos albinos Swiss, respectivamente. A administração de lipopolissacarídeo (LPS,100μg/kg, i.p.) aumentou o tempo que o animal permaneceu boiando no nado forçado e diminuiu a atividade locomotora no campo aberto. O pré-tratamento com EHPv nas doses de 100 e 300 mg/kg, v.o., atenuou as alterações comportamentais induzidas pelo LPS nos testes de nado forçado e campo aberto. Este efeito foi similar ao pré-tratamento com dexametasona (1mg/kg), um fármaco esteroidal que inibe as respostas imunes e inflamatórias, incluindo a produção de citocinas. O EHPv nas doses de 30-300 mg/kg v.o., claramente demonstrou efeitos anti-inflamatórios pela redução do edema de pata induzido por carragenina e inibiu o recrutamento de leucócitos dentro da cavidade peritoneal. Os extratos testados nas doses de 30-300 mg/kg, v.o., claramente demonstraram atividade antinociceptiva nos testes de formalina e contorções abdominais induzidas por ácido acético. O extrato de Pyrostegia venusta atenuou os comportamentos exploratórios e como depressivos, demonstrou ação anti-inflamatória e antinociceptiva em camundongos e nenhuma aparente toxidade aguda na administração oral. Então, nossos resultados suportam prévias indicações do uso dessas plantas nas terapias tradicionais e sugerem que essas plantas podem ser usadas no tratamento de desordens que induzem o comportamento doentio, tais como gripe e resfriado.por
dc.description.abstractPyrostegia venusta (Ker.) Miers (Bignoniaceae) is native to the Brazilian Cerrado and popularly known as “cipó-de-são-joão.” In traditional Brazilian medicine, the Pyrostegia venusta are used as a general tonic as well as a treatment for diarrhea, vitiligo, cough, and common diseases of the respiratory system related to infections, such as bronchitis, flu and cold. This study was conducted to evaluate the effects of a hydroethanolic extrac to flowers of Pyrostegia venusta (PvHE) on sickness behavior induced by lipopolysaccharide in mice, to evaluate the anti-inflammatory and analgesic properties of the PvHE and its phytochemical profile. To evaluate the effects of orally administered Pyrostegia venusta hydroethanolic extract on lipopolysaccharide-induced sickness behavior, mice were submitted to the forced swim test (FST) and the open field test. The PvHE was used to evaluate the anti-inflammatory and analgesic effects using carrageenan-induced paw oedema/ peritonitis and acetic acid-induced writhing/formalin-induced paw licking tests in Swiss albino mice respectively. Lipopolysaccharide (LPS,100μg/kg, i.p.) administration increased the time spent floating in the FST and depressed locomotor activity in the open field. Pretreatment with PvHE at test doses of 100 and 300 mg/kg,p.o. attenuated the behavioral changes induced by LPS in the FST and open field test. This effect was similar to pretreatment with dexamethasone (1mg/kg), which is a steroidal drug that inhibits immune and inflammatory responses, including cytokine production. The PvHE at test doses of 30-300 mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced paw edema induced by carrageenan and inhibited leukocyte recruitment into the peritoneal cavity. The extracts are tested in doses of 30-300 mg/kg, p.o. clearly demonstrated antinociceptive activity in acetic acid-induced writhing and formalin tests. The extract of Pyrostegia venusta attenuated the depressive-like and exploratory behaviors induced by lipopolysaccharide and demonstrated anti-inflammatory and antinociceptive action in mice and no apparent acute toxicity on oral administration. Thus, our results supported previous claims of the usefulness of these plants in traditional therapies and suggest that these plants may Pyrostegia venusta (Ker.) Miers (Bignoniaceae) is native to the Brazilian Cerrado and popularly known as “cipó-de-são-joão.” In traditional Brazilian medicine, the Pyrostegia venusta are used as a general tonic as well as a treatment for diarrhea, vitiligo, cough, and common diseases of the respiratory system related to infections, such as bronchitis, flu and cold. This study was conducted to evaluate the effects of a hydroethanolic extrac to flowers of Pyrostegia venusta (PvHE) on sickness behavior induced by lipopolysaccharide in mice, to evaluate the anti-inflammatory and analgesic properties of the PvHE and its phytochemical profile. To evaluate the effects of orally administered Pyrostegia venusta hydroethanolic extract on lipopolysaccharide-induced sickness behavior, mice were submitted to the forced swim test (FST) and the open field test. The PvHE was used to evaluate the anti-inflammatory and analgesic effects using carrageenan-induced paw oedema/ peritonitis and acetic acid-induced writhing/formalin-induced paw licking tests in Swiss albino mice respectively. Lipopolysaccharide (LPS,100μg/kg, i.p.) administration increased the time spent floating in the FST and depressed locomotor activity in the open field. Pretreatment with PvHE at test doses of 100 and 300 mg/kg,p.o. attenuated the behavioral changes induced by LPS in the FST and open field test. This effect was similar to pretreatment with dexamethasone (1mg/kg), which is a steroidal drug that inhibits immune and inflammatory responses, including cytokine production. The PvHE at test doses of 30-300 mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced paw edema induced by carrageenan and inhibited leukocyte recruitment into the peritoneal cavity. The extracts are tested in doses of 30-300 mg/kg, p.o. clearly demonstrated antinociceptive activity in acetic acid-induced writhing and formalin tests. The extract of Pyrostegia venusta attenuated the depressive-like and exploratory behaviors induced by lipopolysaccharide and demonstrated anti-inflammatory and antinociceptive action in mice and no apparent acute toxicity on oral administration. Thus, our results supported previous claims of the usefulness of these plants in traditional therapies and suggest that these plants may be useful in the treatment of disorders that induced sickness behavior, such as flu and cold.eng
dc.description.provenanceSubmitted by Marlom César da Silva (marlom.silva@unifal-mg.edu.br) on 2015-05-07T23:48:43Z No. of bitstreams: 2 license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e337df6485 (MD5) dissertação clarice final versão final pdf.pdf: 3360964 bytes, checksum: 9db7d553516482c8b53fc3eb629f849a (MD5)eng
dc.description.provenanceApproved for entry into archive by Marlom César da Silva (marlom.silva@unifal-mg.edu.br) on 2015-05-07T23:49:27Z (GMT) No. of bitstreams: 2 license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e337df6485 (MD5) dissertação clarice final versão final pdf.pdf: 3360964 bytes, checksum: 9db7d553516482c8b53fc3eb629f849a (MD5)eng
dc.description.provenanceApproved for entry into archive by Marlom César da Silva (marlom.silva@unifal-mg.edu.br) on 2015-05-07T23:49:39Z (GMT) No. of bitstreams: 2 license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e337df6485 (MD5) dissertação clarice final versão final pdf.pdf: 3360964 bytes, checksum: 9db7d553516482c8b53fc3eb629f849a (MD5)eng
dc.description.provenanceMade available in DSpace on 2015-05-07T23:50:00Z (GMT). No. of bitstreams: 2 license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e337df6485 (MD5) dissertação clarice final versão final pdf.pdf: 3360964 bytes, checksum: 9db7d553516482c8b53fc3eb629f849a (MD5) Previous issue date: 2010-12-16eng
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESpor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal de Alfenaspor
dc.publisher.departmentFaculdade de Ciências Farmacêuticaspor
dc.publisher.countryBrasilpor
dc.publisher.initialsUNIFAL-MGpor
dc.publisher.programPrograma de Pós-Graduação em Ciências Farmacêuticaspor
dc.rightsAcesso Abertopor
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectPyrostegia venustapor
dc.subjectComportamento doentiopor
dc.subjectEfeito anti-inflamatório e analgésicopor
dc.subject.cnpqCIENCIAS DA SAUDE::FARMACIApor
dc.titleAvaliação farmacológica do extrato hidroalcoólico das Flores de Pyrostegia venusta (Ker.) Mierspor
dc.typeDissertaçãopor
Aparece nas coleções:Mestrado

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
dissertação clarice final versão final pdf.pdf3,28 MBAdobe PDFBaixar/Abrir Pré-Visualizar


Este item está licenciada sob uma Licença Creative Commons Creative Commons