O uso indiscriminado do pesticida glifosato poderia aumentar a prevalência da doença de Alzheimer?

Abstract

Pesticides consist of a wide class of environmental contaminants that can cause acute and chronic health effects to individuals exposed to them. These effects can range from simple skin or eye irritation to more serious ones, such as affecting the nervous and reproductive systems and causing cancer. Dementias, including Alzheimer's disease (AD), have attracted the attention of researchers in recent decades due to their high incidence worldwide. The etiology of AD is still not well understood; however, the role of the environment as a risk factor has gained importance. More worrying is the evidence that prenatal and postnatal exposures to environmental factors predispose to the onset of dementia later in life. In several studies, pesticides have been involved in AD due to their ability to increase the Beta-amyloid peptide and the phosphorylation of the Tau protein (P-Tau), causing an increase in the amount of senile/amyloid plaques and neurofibrillary tangles (NFTs) characteristic of AD. This review aims to prospectively verify whether literature data can be used to inform society and, specifically, health professionals, about preventive care and treatment of people and animals that are subjected to contact with glyphosate, including in food.