Síntese e caracterização de ligantes imínicos e complexos de paládio (II). Aspectos estruturais e potencialidades biológicas

Abstract

Organometallic complexes of palladium(II) are obtained, characterized and studied for several decades due to their unusual properties which may be quoted: Supramolecular chemistry, catalysts in homogeneous phase, precursors to obtain liquid crystalline materials, such as anti-neoplastic agents and antirheumatic, among others. Included in this class of complex compounds has been known as cyclometallated and are so called because they have a conformation containing a metal ring. Nitrogen ligands suitable for cyclometallation should be able to form, with the metal, a stable five-membered ring, for example, the ring of N,Ndimetilbenzilamina (dmba). In our recent work showed that organometallic species of palladium(II), cyclometallated or not, containing nitrogen ligands and diphosphines showed significant antitumor potential and they deserve to be explored. Only in recent years, an increase in the number of metal compounds used for therapeutic purposes in the area of scientific research, based on potential interactions of these metal ions with various biomolecules. This new study showed metallic compounds of Pd(II) by addition reaction of metal or cyclometallated ligands. You can then interact the new ligands synthesized with metals such as nitrogen, for example, palladium(II), nickel(II) and platinum(II) and with this model cyclometallated new species or not, with potential antitumor and or anti-leishmaniasis. In this study, we attempted to synthesize and characterize imine ligands and complexes of palladium(II) through of spectroscopic techniques.