@MASTERSTHESIS{ 2022:1252305941,
 	title = {Molecular docking study involving bioactive natural compounds against SARS-CoV-2 proteins.},
 	year = {2022},
 	url = "https://bdtd.unifal-mg.edu.br:8443/handle/tede/2007",
 	abstract = "At the end of 2019, atypical cases of pneumonia accompanied by particular
 symptoms started being reported in the Chinese city of Wuhan. After a few
 weeks had passed, the aforementioned disease spread throughout China and
 became a global pandemic some months later. Severe Acute Respiratory
 Syndrome Coronavirus 2 (SARS-CoV-2) is the etiological agent of that atypical
 pneumonia, which has been named Coronavirus Disease 2019 (COVID-19). In
 an attempt to find an efficient therapy to either fight the spread of COVID-19 or
 to cure infected people from its tissue damages, researchers around the world
 have been studying several plants, herbs and natural products. These potential
 medicines have been used for therapeutic purposes throughout the years due
 to the great variety of bioactive compounds characterizing them. The present
 work aimed to perform virtual screenings by using AutoDock Vina software to
 execute molecular docking studies of tridimensional (3D) structures of well-
 known bioactive natural compounds against 24 SARS-CoV-2 proteins. We have
 analyzed energy scores (provided in -Kcal/mol) as well as ligand-protein
 
 intermolecular binding interactions. In vitro and in vivo assays should be
 furtherly conducted to corroborate with our findings and therefore validate
 chemical substances derived from plants and herbs, such as Punica granatum,
 Centella asiatica and Solanum spp., as promising drug candidates to either
 treat or prevent COVID-19.",
 	publisher = {Universidade Federal de Alfenas},
 	scholl = {Programa de Pós-graduação em Ciências Biológicas},
 	note = {Instituto de Ciências da Natureza}
}